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What is Oxidative Stress?
Oxidative stress, that is, reactive oxygen derivatives, leads to decreased motility, deformity and DNA breaks in the sperm cell. This situation takes the first place in male infertility of unknown cause.
Oxidative Stress
Aggressive molecules formed during the use of oxygen taken into the human body and during metabolism are free radicals. Normally, the body keeps free radicals under control.
However, sometimes the balance can be disturbed and a large number of free radicals are formed, which is called oxidative stress.
Ros (Oxidative Stress Test)
The ROS, namely reactive oxidative stress test with the MIOXSYS device, which has been successfully applied in our center, is a very promising test to contribute significantly to this goal. Oxidative stress, that is, reactive oxygen derivatives, leads to decreased motility, deformity and DNA breaks in the sperm cell. This situation takes the first place in male infertility of unknown cause.
What is the Importance of Oxidative Stress in IVF Treatment? To Whom Is It Applied?
Approximately 50% of couples who cannot have children in normal ways experience this situation due to reasons related to the man, namely sperm quality and number. As it is known, successful and expert embryologists and laboratories with advanced technical equipment have a pregnancy rate of 45-70% with the microinjection procedure. In order to improve this situation, the medical world is in search of alternative supportive treatment methods.
Even if semen morphology and number appear normal, increased ROS levels may reduce the success of IVF treatment. In patients with high ROS levels, it would be appropriate to use a micro filter to sort out the sperm in terms of DNA fragmentation, or to take antioxidant therapy for a certain period of time.
What is the Effect of Oxidative Stress on Female and Male Infertility?
Oxidative stress, which is one of the important causes of male infertility, causes damage such as decrease in sperm quality and function, sperm motility (motility), deterioration in viability, damage to sperm DNA, deterioration in sperm oocyte fusion.
It plays a role in female infertility, reproductive diseases such as endometriosis, polycystic ovary syndrome, unexplained infertility and age-related decrease in fertilization.